1EVE
THREE DIMENSIONAL STRUCTURE OF THE ANTI-ALZHEIMER DRUG, E2020 (ARICEPT), COMPLEXED WITH ITS TARGET ACETYLCHOLINESTERASE
Summary for 1EVE
Entry DOI | 10.2210/pdb1eve/pdb |
Descriptor | ACETYLCHOLINESTERASE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | alzheimer's disease, drug, serine hydrolase, alpha/beta hydrolase, neurotransmitter cleavage, catalytic triad, glycosylated protein |
Biological source | Torpedo californica (Pacific electric ray) |
Cellular location | Isoform H: Cell membrane; Lipid-anchor, GPI- anchor. Isoform T: Cell membrane; Peripheral membrane protein: P04058 |
Total number of polymer chains | 1 |
Total formula weight | 62792.61 |
Authors | Kryger, G.,Silman, I.,Sussman, J.L. (deposition date: 1998-03-04, release date: 1999-01-20, Last modification date: 2023-08-09) |
Primary citation | Kryger, G.,Silman, I.,Sussman, J.L. Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs. Structure Fold.Des., 7:297-307, 1999 Cited by PubMed: 10368299DOI: 10.1016/S0969-2126(99)80040-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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