1EV2
CRYSTAL STRUCTURE OF FGF2 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 2 (FGFR2)
Summary for 1EV2
Entry DOI | 10.2210/pdb1ev2/pdb |
Related | 1CVS 1EVT |
Descriptor | PROTEIN (FIBROBLAST GROWTH FACTOR 2), PROTEIN (FIBROBLAST GROWTH FACTOR RECEPTOR 2), SULFATE ION, ... (4 entities in total) |
Functional Keywords | immunoglobulin (ig)like domains belonging to the i-set subgroup within ig-like domains, b-trefoil fold, growth factor-growth factor receptor complex, growth factor/growth factor receptor |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted: P21802 |
Total number of polymer chains | 8 |
Total formula weight | 159389.34 |
Authors | Plotnikov, A.N.,Hubbard, S.R.,Schlessinger, J.,Mohammadi, M. (deposition date: 2000-04-19, release date: 2000-05-31, Last modification date: 2021-11-03) |
Primary citation | Plotnikov, A.N.,Hubbard, S.R.,Schlessinger, J.,Mohammadi, M. Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. Cell(Cambridge,Mass.), 101:413-424, 2000 Cited by PubMed: 10830168DOI: 10.1016/S0092-8674(00)80851-X PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
Download full validation report