1ETE

CRYSTAL STRUCTURE OF THE FLT3 LIGAND

1ETE の概要

• エントリーDOI: 10.2210/pdb1ete/pdb
• 分子名称: FLT3 LIGAND, ZINC ION (3 entities in total)
• 機能のキーワード: four-helix bundle, cytokine
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P49771
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 62371.55

構造登録者

Savvides, S.N.,Boone, T.,Karplus, P.A. (登録日: 2000-04-12, 公開日: 2000-06-14, 最終更新日: 2024-11-06)

主引用文献

Savvides, S.N.,Boone, T.,Andrew Karplus, P.
Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots.
Nat.Struct.Biol., 7:486-491, 2000

PubMed Abstract: Human Flt3 ligand (Flt3L) stimulates early hematopoiesis by activating a type III tyrosine kinase receptor on primitive bone marrow stem cells. The crystal structure of soluble Flt3L reveals that it is a homodimer of two short chain alpha-helical bundles. Comparisons of structure-function relationships of Flt3L with the homologous hematopoietic cytokines macrophage colony stimulating factor (MCSF) and stem cell factor (SCF) suggest that they have a common receptor binding mode that is distinct from the paradigm derived from the complex of growth hormone with its receptor. Furthermore, we identify recognition features common to all helical and cystine-knot protein ligands that activate type III tyrosine kinase receptors, and the closely related type V tyrosine kinase receptors.

PubMed: 10881197
DOI: 10.1038/75896

実験手法

X-RAY DIFFRACTION (2.2 Å)