1ERU
HUMAN THIOREDOXIN (OXIDIZED FORM)
Summary for 1ERU
| Entry DOI | 10.2210/pdb1eru/pdb |
| Descriptor | THIOREDOXIN (2 entities in total) |
| Functional Keywords | oxidoreductase |
| Biological source | Homo sapiens (human) |
| Cellular location | Nucleus : P10599 |
| Total number of polymer chains | 1 |
| Total formula weight | 11750.48 |
| Authors | Weichsel, A.,Gasdaska, J.R.,Powis, G.,Montfort, W.R. (deposition date: 1996-02-07, release date: 1996-08-01, Last modification date: 2024-10-23) |
| Primary citation | Weichsel, A.,Gasdaska, J.R.,Powis, G.,Montfort, W.R. Crystal structures of reduced, oxidized, and mutated human thioredoxins: evidence for a regulatory homodimer. Structure, 4:735-751, 1996 Cited by PubMed Abstract: Human thioredoxin reduces the disulfide bonds of numerous proteins in vitro, and can activate transcription factors such as NFkB in vivo. Thioredoxin can also act as a growth factor, and is overexpressed and secreted in certain tumor cells. PubMed: 8805557DOI: 10.1016/S0969-2126(96)00079-2 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report
