1ERN

NATIVE STRUCTURE OF THE EXTRACELLULAR DOMAIN OF ERYTHROPOIETIN (EPO) RECEPTOR [EBP]

Summary for 1ERN

Entry DOI	10.2210/pdb1ern/pdb
Descriptor	PROTEIN (ERYTHROPOIETIN RECEPTOR) (2 entities in total)
Functional Keywords	erythropoietin receptor, signal transduction, cytokine receptor class 1, cytokine
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Single-pass type I membrane protein. Isoform EPOR-S: Secreted: P19235
Total number of polymer chains	2
Total formula weight	47023.32
Authors	Livnah, O.,Stura, E.A.,Wilson, I.A. (deposition date: 1999-01-11, release date: 2000-01-07, Last modification date: 2023-08-09)
Primary citation	Livnah, O.,Stura, E.A.,Middleton, S.A.,Johnson, D.L.,Jolliffe, L.K.,Wilson, I.A. Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation. Science, 283:987-990, 1999 Cited by PubMed: 9974392 DOI: 10.1126/science.283.5404.987 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation