1EPQ

ENDOTHIA ASPARTIC PROTEINASE (ENDOTHIAPEPSIN) COMPLEXED WITH PD-133,450 (SOT PHE GLY+SCC GCL)

Summary for 1EPQ

Entry DOI	10.2210/pdb1epq/pdb
Related	1epp
Related PRD ID	PRD_000356
Descriptor	ENDOTHIAPEPSIN, N-[(1S)-2-{[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino}-1-(ethylsulfanyl)-2-oxoethyl]-Nalpha-(morpholin-4-ylsulfonyl)-L-phenylalaninamide, SULFATE ION, ... (4 entities in total)
Functional Keywords	hydrolase-hydrolase inhibitor complex, acid proteinase, hydrolase/hydrolase inhibitor
Biological source	Cryphonectria parasitica (chestnut blight fungus)
Total number of polymer chains	1
Total formula weight	34662.88
Authors	Dealwis, C.,Cooper, J.B.,Blundell, T.L. (deposition date: 1994-07-27, release date: 1994-12-20, Last modification date: 2020-05-27)
Primary citation	Lunney, E.A.,Hamilton, H.W.,Hodges, J.C.,Kaltenbronn, J.S.,Repine, J.T.,Badasso, M.,Cooper, J.B.,Dealwis, C.,Wallace, B.A.,Lowther, W.T. Analyses of ligand binding in five endothiapepsin crystal complexes and their use in the design and evaluation of novel renin inhibitors. J.Med.Chem., 36:3809-3820, 1993 Cited by PubMed: 8254610 DOI: 10.1021/jm00076a008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation