1EPO

ENDOTHIA ASPARTIC PROTEINASE (ENDOTHIAPEPSIN) COMPLEXED WITH CP-81,282 (MOR PHE NLE CHF NME)

Summary for 1EPO

Entry DOI	10.2210/pdb1epo/pdb
Related PRD ID	PRD_000416
Descriptor	ENDOTHIAPEPSIN, N-(morpholin-4-ylcarbonyl)-L-phenylalanyl-N-[(1R)-1-(cyclohexylmethyl)-3,3-difluoro-2,2-dihydroxy-4-(methylamino)-4-oxobutyl]-L-norleucinamide (3 entities in total)
Functional Keywords	acid proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Cryphonectria parasitica (chestnut blight fungus)
Total number of polymer chains	1
Total formula weight	34467.61
Authors	Veerapandian, B.,Cooper, J.B.,Blundell, T.L. (deposition date: 1994-07-27, release date: 1994-12-20, Last modification date: 2017-11-29)
Primary citation	Veerapandian, B.,Cooper, J.B.,Sali, A.,Blundell, T.L.,Rosati, R.L.,Dominy, B.W.,Damon, D.B.,Hoover, D.J. Direct observation by X-ray analysis of the tetrahedral intermediate of aspartic proteinases. Protein Sci., 1:322-328, 1992 Cited by PubMed: 1304340 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation