1EPO

ENDOTHIA ASPARTIC PROTEINASE (ENDOTHIAPEPSIN) COMPLEXED WITH CP-81,282 (MOR PHE NLE CHF NME)

Summary for 1EPO

Related PRD IDPRD_000416
DescriptorENDOTHIAPEPSIN, N-(morpholin-4-ylcarbonyl)-L-phenylalanyl-N-[(1R)-1-(cyclohexylmethyl)-3,3-difluoro-2,2-dihydroxy-4-(methylamino)-4-oxobutyl]-L-norleucinamide (3 entities in total)
Functional Keywordsacid proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceCryphonectria parasitica (chestnut blight fungus)
Total number of polymer chains1
Total molecular weight34467.61
Authors
Veerapandian, B.,Cooper, J.B.,Blundell, T.L. (deposition date: 1994-07-27, release date: 1994-12-20, Last modification date: 2017-11-29)
Primary citation
Veerapandian, B.,Cooper, J.B.,Sali, A.,Blundell, T.L.,Rosati, R.L.,Dominy, B.W.,Damon, D.B.,Hoover, D.J.
Direct observation by X-ray analysis of the tetrahedral intermediate of aspartic proteinases.
Protein Sci., 1:322-328, 1992
PubMed: 1304340 (PDB entries with the same primary citation)
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers71.5%6.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report