1EEU

M4L/Y(27D)D/Q89D/T94H mutant of LEN

Summary for 1EEU

Related1EEQ
DescriptorKAPPA-4 IMMUNOGLOBULIN (LIGHT CHAIN), ISOPROPYL ALCOHOL (3 entities in total)
Functional Keywordshuman kappa-4 immunoglobulin light chain, mutant, aspartic acid in beta-sheet, protein stability, immune system
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total molecular weight25335.97
Authors
Pokkuluri, P.R.,Cai, X.,Gu, M.,Stevens, F.J.,Schiffer, M. (deposition date: 2000-02-03, release date: 2001-02-03, Last modification date: 2011-07-13)
Primary citation
Pokkuluri, P.R.,Gu, M.,Cai, X.,Raffen, R.,Stevens, F.J.,Schiffer, M.
Factors contributing to decreased protein stability when aspartic acid residues are in beta-sheet regions.
Protein Sci., 11:1687-1694, 2002
PubMed: 12070321 (PDB entries with the same primary citation)
DOI: 10.1110/ps.4920102
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.6 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2283002.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution