1EE4

CRYSTAL STRUCTURE OF YEAST KARYOPHERIN (IMPORTIN) ALPHA IN A COMPLEX WITH A C-MYC NLS PEPTIDE

1EE4 の概要

• エントリーDOI: 10.2210/pdb1ee4/pdb
• 関連するPDBエントリー: 1BK6 1EE5
• 分子名称: KARYOPHERIN ALPHA, MYC PROTO-ONCOGENE PROTEIN (3 entities in total)
• 機能のキーワード: arm repeat, transport protein
• 由来する生物種: Saccharomyces cerevisiae (baker's yeast); 詳細
• 細胞内の位置: Cytoplasm, perinuclear region: Q02821; Nucleus, nucleoplasm: P01106
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 97741.91

構造登録者

Conti, E. (登録日: 2000-01-30, 公開日: 2000-03-29, 最終更新日: 2024-02-07)

主引用文献

Conti, E.,Kuriyan, J.
Crystallographic analysis of the specific yet versatile recognition of distinct nuclear localization signals by karyopherin alpha.
Structure Fold.Des., 8:329-338, 2000

PubMed Abstract: Karyopherin alpha (importin alpha) is an adaptor molecule that recognizes proteins containing nuclear localization signals (NLSs). The prototypical NLS that is able to bind to karyopherin alpha is that of the SV40 T antigen, and consists of a short positively charged sequence motif. Distinct classes of NLSs (monopartite and bipartite) have been identified that are only partly conserved with respect to one another but are nevertheless recognized by the same receptor.

PubMed: 10745017
DOI: 10.1016/S0969-2126(00)00107-6

実験手法

X-RAY DIFFRACTION (2.1 Å)