1EC2

HIV-1 protease in complex with the inhibitor BEA428

1EC2 の概要

• エントリーDOI: 10.2210/pdb1ec2/pdb
• 関連するPDBエントリー: 1AJV 1AJX 1D4H 1D4I 1D4J 1EBW 1EBY 1EBZ 1EC0 1EC1 1EC3
• 分子名称: HIV-1 PROTEASE, N,N-[2,5-O-[DI-4-PYRIDIN-3-YL-BENZYL]-GLUCARYL]-DI-[VALYL-AMIDO-METHANE] (3 entities in total)
• 機能のキーワード: dimer, protein-inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22376.41

構造登録者

Unge, T. (登録日: 2000-01-25, 公開日: 2002-06-26, 最終更新日: 2024-02-07)

• 主引用文献: Andersson, H.O.,Fridborg, K.,Lowgren, S.,Alterman, M.,Muhlman, A.,Bjorsne, M.,Garg, N.,Kvarnstrom, I.,Schaal, W.,Classon, B.,Karlen, A.,Danielsson, U.H.,Ahlsen, G.,Nillroth, U.,Vrang, L.,Oberg, B.,Samuelsson, B.,Hallberg, A.,Unge, T.; Optimization of P1-P3 groups in symmetric and asymmetric HIV-1 protease inhibitors; Eur.J.Biochem., 270:1746-1758, 2003; PubMed: 12694187; DOI: 10.1046/j.1432-1033.2003.03533.x

実験手法

X-RAY DIFFRACTION (2 Å)