1D4H

HIV-1 Protease in complex with the inhibitor BEA435

Summary for 1D4H

• Entry DOI: 10.2210/pdb1d4h/pdb
• Related: 1AJV 1AJX 1D4H 1D4I 1D4J
• Descriptor: HIV-1 PROTEASE, 2,5-DIBENZYLOXY-3,4-DIHYDROXY-HEXANEDIOIC ACID BENZYLAMIDE (2-HYDROXY-INDAN-1-YL)-AMIDE (3 entities in total)
• Functional Keywords: dimer, hydrolase
• Biological source: Human immunodeficiency virus
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366
• Total number of polymer chains: 2
• Total formula weight: 22218.21

Authors

Unge, T. (deposition date: 1999-10-04, release date: 2002-06-26, Last modification date: 2024-02-07)

• Primary citation: Andersson, H.O.,Fridborg, K.,Lowgren, S.,Alterman, M.,Muhlman, A.,Bjorsne, M.,Garg, N.,Kvarnstrom, I.,Schaal, W.,Classon, B.,Danielsson, U.H.,Ahlsen, G.,Nillroth, U.,Vrang, L.,Oberg, B.,Samuelsson, B.,Hallberg, A.,Unge, T.; Optimization of P1-P3 groups in symmetric and asymmetric HIV-1 protease inhibitors.; Eur.J.Biochem., 270:1746-1758, 2003; PubMed: 12694187; DOI: 10.1046/j.1432-1033.2003.03533.x

Experimental method

X-RAY DIFFRACTION (1.81 Å)