1EAT

NONPEPTIDIC INHIBITORS OF HUMAN LEUKOCYTE ELASTASE. 5. DESIGN, SYNTHESIS, AND X-RAY CRYSTALLOGRAPHY OF A SERIES OF ORALLY ACTIVE 5-AMINO-PYRIMIDIN-6-ONE-CONTAINING TRIFLUOROMETHYLKETONES

1EAT の概要

• エントリーDOI: 10.2210/pdb1eat/pdb
• 分子名称: PORCINE PANCREATIC ELASTASE, SODIUM ION, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: hydrolase (serine protease)
• 由来する生物種: Sus scrofa (pig)
• 細胞内の位置: Secreted: P00772
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26632.62

構造登録者

Ceccarelli, C. (登録日: 1994-11-22, 公開日: 1995-02-07, 最終更新日: 2012-02-22)

• 主引用文献: Veale, C.A.,Bernstein, P.R.,Bryant, C.,Ceccarelli, C.,Damewood Jr., J.R.,Earley, R.,Feeney, S.W.,Gomes, B.,Kosmider, B.J.,Steelman, G.B.,Thomas, R.M.,Vacek, E.P.,Williams, J.C.,Wolanin, D.J.,Woolson, S.; Nonpeptidic inhibitors of human leukocyte elastase. 5. Design, synthesis, and X-ray crystallography of a series of orally active 5-aminopyrimidin-6-one-containing trifluoromethyl ketones.; J.Med.Chem., 38:98-108, 1995; PubMed: 7837246; DOI: 10.1021/jm00001a015

実験手法

X-RAY DIFFRACTION (2 Å)