1E92
Pteridine reductase 1 from Leishmania major complexed with NADP+ and dihydrobiopterin
Summary for 1E92
Entry DOI | 10.2210/pdb1e92/pdb |
Related | 1E7W |
Descriptor | PTERIDINE REDUCTASE 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 7,8-DIHYDROBIOPTERIN, ... (5 entities in total) |
Functional Keywords | pteridine reductase, trypanosomatids, drug resistance, pterin salvage, short-chain dehydrogenase/reductase |
Biological source | LEISHMANIA MAJOR |
Total number of polymer chains | 4 |
Total formula weight | 125941.14 |
Authors | Schuettelkopf, A.W.,Hunter, W.N. (deposition date: 2000-10-04, release date: 2001-10-05, Last modification date: 2023-12-13) |
Primary citation | Gourley, D.G.,Schuettelkopf, A.W.,Leonard, G.A.,Luba, J.,Hardy, L.W.,Beverley, S.M.,Hunter, W.N. Pteridine Reductase Mechanism Correlates Pterin Metabolism with Drug Resistance in Trypanosomatid Parasites Nat.Struct.Biol., 8:521-, 2001 Cited by PubMed: 11373620DOI: 10.1038/88584 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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