1E3U

MAD structure of OXA10 class D beta-lactamase

1E3U の概要

• エントリーDOI: 10.2210/pdb1e3u/pdb
• 関連するPDBエントリー: 1E4D
• 分子名称: BETA-LACTAMASE OXA-10, GOLD (I) CYANIDE ION, SULFATE ION, ... (6 entities in total)
• 機能のキーワード: beta-lactamase, antiobitic resistance
• 由来する生物種: PSEUDOMONAS AERUGINOSA; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 114256.96

構造登録者

Maveyraud, L.,Golemi, D.,Kotra, L.P.,Tranier, S.,Vakulenko, S.,Mobashery, S.,Samama, J.P. (登録日: 2000-06-23, 公開日: 2001-01-12, 最終更新日: 2024-10-16)

主引用文献

Maveyraud, L.,Golemi, D.,Kotra, L.P.,Tranier, S.,Vakulenko, S.,Mobashery, S.,Samama, J.P.
Insights Into Class D Beta-Lactamases are Revealed by the Crystal Structure of the Oxa10 Enzyme from Pseudomonas Aeruginosa
Structure, 8:1289-, 2000

PubMed Abstract: beta-lactam antibiotic therapies are commonly challenged by the hydrolytic activities of beta-lactamases in bacteria. These enzymes have been grouped into four classes: A, B, C, and D. Class B beta-lactamases are zinc dependent, and enzymes of classes A, C, and D are transiently acylated on a serine residue in the course of the turnover chemistry. While class A and C beta-lactamases have been extensively characterized by biochemical and structural methods, class D enzymes remain the least studied despite their increasing importance in the clinic.

PubMed: 11188693
DOI: 10.1016/S0969-2126(00)00534-7

実験手法

X-RAY DIFFRACTION (1.66 Å)