1E26

Design, Synthesis and X-ray Crystal Structure of a Potent Dual Inhibitor of Thymidylate Synthase and Dihydrofolate Reductase as an Antitumor Agent.

Summary for 1E26

Entry DOI	10.2210/pdb1e26/pdb
Related	1DAJ 1DYR 2CD2 3CD2 4CD2
Descriptor	DIHYDROFOLATE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-[4-[2-(2-AMINO-4-METHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYL]GLUTAMIC ACID, ... (4 entities in total)
Functional Keywords	oxidoreductase, dihydrofolate reductase, thymidylate synthase
Biological source	PNEUMOCYSTIS CARINII
Total number of polymer chains	1
Total formula weight	25087.38
Authors	Gangjee, A.,Yu, J.,McGuire, J.J.,Cody, V.,Galitsky, N.,Kisliuk, R.L.,Queener, S.F. (deposition date: 2000-05-17, release date: 2001-05-17, Last modification date: 2023-12-06)
Primary citation	Cody, V.,Galitsky, N.,Rak, D.,Luft, J.R.,Pangborn, W.,Queener, S.F. Ligand-Induced Conformational Changes in the Crystal Structures of Pneumocystis Carinii Dihydrofolate Reductase Complexes with Folate and Nadp+ Biochemistry, 38:4303-, 1999 Cited by PubMed: 10194348 DOI: 10.1021/BI982728M PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation