1DXP

Inhibition of the Hepatitis C Virus NS3/4A Protease. The Crystal Structures of Two Protease-Inhibitor Complexes (apo structure)

Summary for 1DXP

Entry DOI	10.2210/pdb1dxp/pdb
Related	1DY8 1DY9 1JXP
Descriptor	PROTEASE/HELICASE NS3 (P70), NONSTRUCTURAL PROTEIN NS4A (P4), ZINC ION, ... (5 entities in total)
Functional Keywords	serine protease, ns3, ns4a, hepatitis c virus, protease inhibition, hydrolase
Biological source	HEPATITIS C VIRUS (ISOLATE TAIWAN) More
Total number of polymer chains	4
Total formula weight	43094.21
Authors	Di Marco, S.,Rizzi, M.,Volpari, C.,Walsh, M.,Narjes, F.,Colarusso, S.,De Francesco, R.,Matassa, V.G.,Sollazzo, M. (deposition date: 2000-01-13, release date: 2001-01-12, Last modification date: 2023-12-06)
Primary citation	Di Marco, S.,Rizzi, M.,Volpari, C.,Walsh, M.,Narjes, F.,Colarusso, S.,De Francesco, R.,Matassa, V.G.,Sollazzo, M. Inhibition of the Hepatitis C Virus Ns3/4A Protease the Crystal Structures of Two Protease-Inhibitor Complexes J.Biol.Chem., 275:7152-, 2000 Cited by PubMed: 10702283 DOI: 10.1074/JBC.275.10.7152 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation