1DTG

HUMAN TRANSFERRIN N-LOBE MUTANT H249E

1DTG の概要

• エントリーDOI: 10.2210/pdb1dtg/pdb
• 分子名称: TRANSFERRIN, FE (III) ION, CARBONATE ION, ... (4 entities in total)
• 機能のキーワード: iron transport, glycoprotein, metal-binding, polymorphism, 3d- structure, metal transport
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P02787
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36994.76

構造登録者

MacGillivray, R.T.,Bewley, M.C.,Smith, C.A.,He, Q.Y.,Mason, A.B. (登録日: 2000-01-12, 公開日: 2000-01-21, 最終更新日: 2021-11-03)

• 主引用文献: MacGillivray, R.T.,Bewley, M.C.,Smith, C.A.,He, Q.Y.,Mason, A.B.; Mutation of the iron ligand His 249 to Glu in the N-lobe of human transferrin abolishes the dilysine "trigger" but does not significantly affect iron release.; Biochemistry, 39:1211-1216, 2000; PubMed: 10684598; DOI: 10.1021/bi991522y

実験手法

X-RAY DIFFRACTION (2.4 Å)