1DMO

CALMODULIN, NMR, 30 STRUCTURES

Summary for 1DMO

Entry DOI	10.2210/pdb1dmo/pdb
Descriptor	CALMODULIN (1 entity in total)
Functional Keywords	calcium-induced conformational change, calcium-binding protein
Biological source	Xenopus laevis (African clawed frog)
Total number of polymer chains	1
Total formula weight	16720.36
Authors	Zhang, M.,Tanaka, T.,Ikura, M. (deposition date: 1996-04-24, release date: 1996-08-01, Last modification date: 2024-05-22)
Primary citation	Zhang, M.,Tanaka, T.,Ikura, M. Calcium-induced conformational transition revealed by the solution structure of apo calmodulin. Nat.Struct.Biol., 2:758-767, 1995 Cited by PubMed Abstract: The solution structure of Ca(2+)-free calmodulin has been determined by NMR spectroscopy, and is compared to the previously reported structure of the Ca(2+)-saturated form. The removal of Ca2+ causes the interhelical angles of four EF-hand motifs to increase by 36 degrees-44 degrees. This leads to major changes in surface properties, including the closure of the deep hydrophobic cavity essential for target protein recognition. Concerted movements of helices A and D with respect to B and C, and of helices E and H with respect to F and G are likely responsible for the cooperative Ca(2+)-binding property observed between two adjacent EF-hand sites in the amino- and carboxy-terminal domains. PubMed: 7552747 DOI: 10.1038/nsb0995-758 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation