1DL8

CRYSTAL STRUCTURE OF 5-F-9-AMINO-(N-(2-DIMETHYLAMINO)ETHYL)ACRIDINE-4-CARBOXAMIDE BOUND TO D(CGTACG)2

Summary for 1DL8

• Entry DOI: 10.2210/pdb1dl8/pdb
• Descriptor: DNA (5'-D(*CP*GP*TP*AP*CP*G)-3'), 5-FLUORO-9-AMINO-(N-(2-DIMETHYLAMINO)ETHYL)ACRIDINE-4-CARBOXAMIDE (3 entities in total)
• Functional Keywords: intercalation, dna, acridine
• Total number of polymer chains: 1
• Total formula weight: 2461.95

Authors

Adams, A.,Guss, J.M.,Collyer, C.A.,Denny, W.A.,Wakelin, L.P. (deposition date: 1999-12-08, release date: 2000-10-30, Last modification date: 2024-04-03)

• Primary citation: Adams, A.,Guss, J.M.,Collyer, C.A.,Denny, W.A.,Prakash, A.S.,Wakelin, L.P.; Acridinecarboxamide topoisomerase poisons: structural and kinetic studies of the DNA complexes of 5-substituted 9-amino-(N-(2-dimethylamino)ethyl)acridine-4-carboxamides.; Mol.Pharmacol., 58:649-658, 2000; PubMed: 10953060

Experimental method

X-RAY DIFFRACTION (1.55 Å)