1DJP

CRYSTAL STRUCTURE OF PSEUDOMONAS 7A GLUTAMINASE-ASPARAGINASE WITH THE INHIBITOR DON COVALENTLY BOUND IN THE ACTIVE SITE

1DJP の概要

• エントリーDOI: 10.2210/pdb1djp/pdb
• 関連するPDBエントリー: 1DJO 4PGA
• 分子名称: GLUTAMINASE-ASPARAGINASE, 5,5-dihydroxy-6-oxo-L-norleucine (3 entities in total)
• 機能のキーワード: pga, glutaminase, asparaginase, don, 6-diazo-5-oxo-l-norvaline, glutaminase-asparaginase, suicide inhibitor, covalently bound inhibitor, hydrolase
• 由来する生物種: Pseudomonas sp.
• 細胞内の位置: Periplasm: P10182
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71146.36

構造登録者

Ortlund, E.,Lacount, M.W.,Lewinski, K.,Lebioda, L. (登録日: 1999-12-03, 公開日: 2000-01-24, 最終更新日: 2017-10-04)

• 主引用文献: Ortlund, E.,Lacount, M.W.,Lewinski, K.,Lebioda, L.; Reactions of Pseudomonas 7A glutaminase-asparaginase with diazo analogues of glutamine and asparagine result in unexpected covalent inhibitions and suggests an unusual catalytic triad Thr-Tyr-Glu.; Biochemistry, 39:1199-1204, 2000; PubMed: 10684596; DOI: 10.1021/bi991797d

実験手法

X-RAY DIFFRACTION (1.9 Å)