1DIF

HIV-1 PROTEASE IN COMPLEX WITH A DIFLUOROKETONE CONTAINING INHIBITOR A79285

Summary for 1DIF

DescriptorHIV-1 PROTEASE, BETA-MERCAPTOETHANOL, N-{1-BENZYL-2,2-DIFLUORO-3,3-DIHYDROXY-4-[3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRYLAMINO]-5-PHENYL-PENTYL}-3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRAMIDE, ... (4 entities in total)
Functional Keywordsaspartic proteinase
Biological sourceHuman immunodeficiency virus 1
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential) P03367
Total number of polymer chains2
Total molecular weight22594.74
Authors
Silva, A.M.,Cachau, R.E.,Sham, H.L.,Erickson, J.W. (deposition date: 1995-10-09, release date: 1996-03-08, Last modification date: 2011-07-13)
Primary citation
Silva, A.M.,Cachau, R.E.,Sham, H.L.,Erickson, J.W.
Inhibition and catalytic mechanism of HIV-1 aspartic protease.
J.Mol.Biol., 255:321-346, 1996
PubMed: 8551523 (PDB entries with the same primary citation)
DOI: 10.1006/jmbi.1996.0026
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.7 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers202.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution