1DI9

THE STRUCTURE OF P38 MITOGEN-ACTIVATED PROTEIN KINASE IN COMPLEX WITH 4-[3-METHYLSULFANYLANILINO]-6,7-DIMETHOXYQUINAZOLINE

1DI9 の概要

• エントリーDOI: 10.2210/pdb1di9/pdb
• 関連するPDBエントリー: 1DI8
• 分子名称: P38 KINASE, 4-[3-METHYLSULFANYLANILINO]-6,7-DIMETHOXYQUINAZOLINE (3 entities in total)
• 機能のキーワード: serine/threonine protein kinase, map kinase, p38, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm (By similarity): Q16539
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41670.60

構造登録者

Shewchuk, L.,Hassell, A.,Kuyper, L.F. (登録日: 1999-11-29, 公開日: 2000-11-29, 最終更新日: 2024-02-07)

• 主引用文献: Shewchuk, L.,Hassell, A.,Wisely, B.,Rocque, W.,Holmes, W.,Veal, J.,Kuyper, L.F.; Binding mode of the 4-anilinoquinazoline class of protein kinase inhibitor: X-ray crystallographic studies of 4-anilinoquinazolines bound to cyclin-dependent kinase 2 and p38 kinase.; J.Med.Chem., 43:133-138, 2000; PubMed: 10633045; DOI: 10.1021/jm990401t

実験手法

X-RAY DIFFRACTION (2.6 Å)