1DG7

DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND 4-BROMO WR99210

Summary for 1DG7

• Entry DOI: 10.2210/pdb1dg7/pdb
• Related: 1DF7 1DG5 1DG8
• Descriptor: DIHYDROFOLATE REDUCTASE, 1-[3-(4-BROMO-PHENOXY)-PROPOXY]-6,6-DIMETHYL-1.6-DIHYDRO-[1,3,5]TRIAZINE-2,4-DIAMINE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
• Functional Keywords: dihydrofolate reductase, structure-based inhibitor design, folateanalogs, rossmann fold, nicotinamide adenine dinucleotide, wr99210, anti-malaria agent, tuberculosis, oxidoreductase
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 1
• Total formula weight: 19145.03

Authors

Li, R.,Sirawaraporn, R.,Chitnumsub, P.,Sirawaraporn, W.,Wooden, J.,Athappilly, F.,Turley, S.,Hol, W.G. (deposition date: 1999-11-23, release date: 2000-03-09, Last modification date: 2024-02-07)

• Primary citation: Li, R.,Sirawaraporn, R.,Chitnumsub, P.,Sirawaraporn, W.,Wooden, J.,Athappilly, F.,Turley, S.,Hol, W.G.; Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs.; J.Mol.Biol., 295:307-323, 2000; PubMed: 10623528; DOI: 10.1006/jmbi.1999.3328

Experimental method

X-RAY DIFFRACTION (1.8 Å)