1DG7

DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND 4-BROMO WR99210

1DG7 の概要

• エントリーDOI: 10.2210/pdb1dg7/pdb
• 関連するPDBエントリー: 1DF7 1DG5 1DG8
• 分子名称: DIHYDROFOLATE REDUCTASE, 1-[3-(4-BROMO-PHENOXY)-PROPOXY]-6,6-DIMETHYL-1.6-DIHYDRO-[1,3,5]TRIAZINE-2,4-DIAMINE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
• 機能のキーワード: dihydrofolate reductase, structure-based inhibitor design, folateanalogs, rossmann fold, nicotinamide adenine dinucleotide, wr99210, anti-malaria agent, tuberculosis, oxidoreductase
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19145.03

構造登録者

Li, R.,Sirawaraporn, R.,Chitnumsub, P.,Sirawaraporn, W.,Wooden, J.,Athappilly, F.,Turley, S.,Hol, W.G. (登録日: 1999-11-23, 公開日: 2000-03-09, 最終更新日: 2024-02-07)

• 主引用文献: Li, R.,Sirawaraporn, R.,Chitnumsub, P.,Sirawaraporn, W.,Wooden, J.,Athappilly, F.,Turley, S.,Hol, W.G.; Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs.; J.Mol.Biol., 295:307-323, 2000; PubMed: 10623528; DOI: 10.1006/jmbi.1999.3328

実験手法

X-RAY DIFFRACTION (1.8 Å)