1DEW

CRYSTAL STRUCTURE OF HUMAN APE1 BOUND TO ABASIC DNA

Summary for 1DEW

• Entry DOI: 10.2210/pdb1dew/pdb
• Related: 1BIX 1DE8 1DE9
• Descriptor: 5'-D(*GP*CP*GP*TP*CP*CP*(3DR)P*CP*GP*AP*CP*GP*AP*CP*G)-3', 5'-D(*GP*TP*CP*GP*TP*CP*GP*GP*GP*GP*AP*CP*GP*C)-3', MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE, ... (5 entities in total)
• Functional Keywords: enzyme:dna complex, dna repair, abasic site, lyase-dna complex, lyase/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus. DNA-(apurinic or apyrimidinic site) lyase, mitochondrial: Mitochondrion: P27695
• Total number of polymer chains: 6
• Total formula weight: 80629.07

Authors

Mol, C.D.,Izumi, T.,Mitra, S.,Tainer, J.A. (deposition date: 1999-11-15, release date: 2000-02-02, Last modification date: 2024-02-07)

• Primary citation: Mol, C.D.,Izumi, T.,Mitra, S.,Tainer, J.A.; DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination; Nature, 403:451-456, 2000; PubMed: 10667800; DOI: 10.1038/35000249

Experimental method

X-RAY DIFFRACTION (2.65 Å)