1DEM

PROTEINASE INHIBITOR HOMOLOGUES AS POTASSIUM CHANNEL BLOCKERS

Summary for 1DEM

Entry DOI	10.2210/pdb1dem/pdb
Descriptor	DENDROTOXIN I (1 entity in total)
Functional Keywords	venom(potassium channel inhibitor)
Biological source	Dendroaspis polylepis polylepis (black mamba)
Cellular location	Secreted: P00979
Total number of polymer chains	1
Total formula weight	7170.41
Authors	Lancelin, J.-M.,Foray, M.-F. (deposition date: 1994-03-07, release date: 1994-05-31, Last modification date: 2024-10-23)
Primary citation	Lancelin, J.M.,Foray, M.F.,Poncin, M.,Hollecker, M.,Marion, D. Proteinase inhibitor homologues as potassium channel blockers. Nat.Struct.Biol., 1:246-250, 1994 Cited by PubMed Abstract: We report here the NMR structure of dendrotoxin I, a powerful potassium channel blocker from the venom of the African Elapidae snake Dendroaspis polylepis polylepis (black mamba), calculated from an experimentally-derived set of 719 geometric restraints. The backbone of the toxin superimposes on bovine pancreatic trypsin inhibitor (BPTI) with a root-mean-square deviation of < 1.7 A. The surface electrostatic potential calculated for dendrotoxin I and BPTI, reveal an important difference which might account for the differences in function of the two proteins. These proteins may provide examples of adaptation for specific and diverse biological functions while at the same time maintaining the overall three-dimensional structure of a common ancestor. PubMed: 7544683 DOI: 10.1038/nsb0494-246 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation