1DCE

CRYSTAL STRUCTURE OF RAB GERANYLGERANYLTRANSFERASE FROM RAT BRAIN

Summary for 1DCE

• Entry DOI: 10.2210/pdb1dce/pdb
• Descriptor: PROTEIN (RAB GERANYLGERANYLTRANSFERASE ALPHA SUBUNIT), PROTEIN (RAB GERANYLGERANYLTRANSFERASE BETA SUBUNIT), ZINC ION, ... (4 entities in total)
• Functional Keywords: rab geranylgeranyltransferase, 2.0 a resolution, n-formylmethionine, alpha subunit, beta subunit, transferase
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 4
• Total formula weight: 203933.47

Authors

Zhang, H.,Seabra, M.C.,Deisenhofer, H. (deposition date: 1999-11-04, release date: 2000-03-24, Last modification date: 2024-10-16)

Primary citation

Zhang, H.,Seabra, M.C.,Deisenhofer, J.
Crystal structure of Rab geranylgeranyltransferase at 2.0 A resolution.
Structure Fold.Des., 8:241-251, 2000

PubMed Abstract: Rab geranylgeranyltransferase (RabGGT) catalyzes the addition of two geranylgeranyl groups to the C-terminal cysteine residues of Rab proteins, which is crucial for membrane association and function of these proteins in intracellular vesicular trafficking. Unlike protein farnesyltransferase (FT) and type I geranylgeranyltransferase, which both prenylate monomeric small G proteins or short peptides, RabGGT can prenylate Rab only when Rab is in a complex with Rab escort protein (REP).

PubMed: 10745007
DOI: 10.1016/S0969-2126(00)00102-7

Experimental method

X-RAY DIFFRACTION (2 Å)