1DAN

Complex of active site inhibited human blood coagulation factor VIIA with human recombinant soluble tissue factor

Summary for 1DAN

• Entry DOI: 10.2210/pdb1dan/pdb
• Related PRD ID: PRD_000369
• Descriptor: BLOOD COAGULATION FACTOR VIIA light chain, CHLORIDE ION, BLOOD COAGULATION FACTOR VIIA heavy chain, ... (11 entities in total)
• Functional Keywords: blood coagulation, serine protease, co-factor, receptor enzyme, gla, egf, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 70003.49

Authors

Banner, D.W. (deposition date: 1997-03-05, release date: 1997-09-04, Last modification date: 2020-07-29)

Primary citation

Banner, D.W.,D'Arcy, A.,Chene, C.,Winkler, F.K.,Guha, A.,Konigsberg, W.H.,Nemerson, Y.,Kirchhofer, D.
The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor.
Nature, 380:41-46, 1996

PubMed Abstract: Blood coagulation is initiated when tissue factor binds to coagulation factor VIIa to give an enzymatically active complex which then activates factors IX and X, leading to thrombin generation and clot formation. We have determined the crystal structure at 2.0-A degrees resolution of active-site-inhibited factor VIIa complexed with the cleaved extracellular domain of tissue factor. In the complex, factor VIIa adopts an extended conformation. This structure provides a basis for understanding many molecular aspects of the initiation of coagulation.

PubMed: 8598903
DOI: 10.1038/380041a0

Experimental method

X-RAY DIFFRACTION (2 Å)