1D8D

CO-CRYSTAL STRUCTURE OF RAT PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH A K-RAS4B PEPTIDE SUBSTRATE AND FPP ANALOG AT 2.0A RESOLUTION

Summary for 1D8D

• Entry DOI: 10.2210/pdb1d8d/pdb
• Related: 1d8e 1ft1 1ft2
• Descriptor: farnesyltransferase (alpha subunit), farnesyltransferase (beta subunit), K-RAS4B PEPTIDE SUBSTRATE, ... (7 entities in total)
• Functional Keywords: ftase, pft, pftase, farnesyltransferase, farnesyl transferase, caax, ras, cancer, transferase
• Biological source: Rattus norvegicus (Norway rat); More
• Cellular location: Cell membrane; Lipid-anchor; Cytoplasmic side: P01116
• Total number of polymer chains: 3
• Total formula weight: 94780.13

Authors

Long, S.B.,Casey, P.J.,Beese, L.S. (deposition date: 1999-10-22, release date: 2000-02-09, Last modification date: 2024-03-13)

• Primary citation: Long, S.B.,Casey, P.J.,Beese, L.S.; The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures.; Structure Fold.Des., 8:209-222, 2000; PubMed: 10673434; DOI: 10.1016/S0969-2126(00)00096-4

Experimental method

X-RAY DIFFRACTION (2 Å)