1D6N
TERNARY COMPLEX STRUCTURE OF HUMAN HGPRTASE, PRPP, MG2+, AND THE INHIBITOR HPP REVEALS THE INVOLVEMENT OF THE FLEXIBLE LOOP IN SUBSTRATE BINDING
Summary for 1D6N
Entry DOI | 10.2210/pdb1d6n/pdb |
Descriptor | PROTEIN (HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE), MAGNESIUM ION, 3H-PYRAZOLO[4,3-D]PYRIMIDIN-7-OL, ... (5 entities in total) |
Functional Keywords | hgprtase, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P00492 |
Total number of polymer chains | 2 |
Total formula weight | 49144.19 |
Authors | Balendiran, G.K. (deposition date: 1999-10-14, release date: 1999-12-30, Last modification date: 2024-02-07) |
Primary citation | Balendiran, G.K.,Molina, J.A.,Xu, Y.,Torres-Martinez, J.,Stevens, R.,Focia, P.J.,Eakin, A.E.,Sacchettini, J.C.,Craig III, S.P. Ternary complex structure of human HGPRTase, PRPP, Mg2+, and the inhibitor HPP reveals the involvement of the flexible loop in substrate binding. Protein Sci., 8:1023-1031, 1999 Cited by PubMed: 10338013PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
Download full validation report