1D5V

SOLUTION STRUCTURE OF THE FORKHEAD DOMAIN OF THE ADIPOCYTE-TRANSCRIPTION FACTOR FREAC-11 (S12)

Summary for 1D5V

• Entry DOI: 10.2210/pdb1d5v/pdb
• Descriptor: S12 TRANSCRIPTION FACTOR (FKH-14) (1 entity in total)
• Functional Keywords: winged helix, dna-recognition helix, gene regulation
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus (Probable): Q99958
• Total number of polymer chains: 1
• Total formula weight: 11083.72

Authors

van Dongen, M.J.P.,Cederberg, A.,Carlsson, P.,Enerback, S.,Wikstrom, M. (deposition date: 1999-10-12, release date: 2000-10-11, Last modification date: 2024-05-22)

Primary citation

van Dongen, M.J.,Cederberg, A.,Carlsson, P.,Enerback, S.,Wikstrom, M.
Solution structure and dynamics of the DNA-binding domain of the adipocyte-transcription factor FREAC-11.
J.Mol.Biol., 296:351-359, 2000

PubMed Abstract: Transcription factors of the forkhead type share a highly conserved DNA-binding domain of about 100 amino acid residues. FREAC-11, expressed in adipocytes, belongs to this class. Here, we report on NMR studies that established the three-dimensional structure of the FREAC-11, DNA-binding domain. Although apparent similarities to the structures of other members within the forkhead family are observed, the structure also reveals some remarkable differences. Along with the complementary dynamics, the data provide insight into the fundamentals of sequence specificity within a highly conserved motif.

PubMed: 10669593
DOI: 10.1006/jmbi.1999.3476

Experimental method

SOLUTION NMR