1D4W

CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP IN COMPLEX WITH SLAM PHOSPHOPEPTIDE

Summary for 1D4W

• Entry DOI: 10.2210/pdb1d4w/pdb
• Related: 1D1Z 1D4T
• Descriptor: T CELL SIGNAL TRANSDUCTION MOLECULE SAP, SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE (3 entities in total)
• Functional Keywords: sh2 domain, phosphotyrosine recogniiton, peptide recognition, signal transduction, lymphoproliferative disease, signaling protein
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm : O60880; Cell membrane ; Single-pass type I membrane protein. Isoform 3: Secreted . Isoform 4: Cell membrane : Q13291
• Total number of polymer chains: 4
• Total formula weight: 26125.77

Authors

Poy, F.,Yaffe, M.B.,Sayos, J.,Saxena, K.,Eck, M.J. (deposition date: 1999-10-06, release date: 1999-10-14, Last modification date: 2018-01-31)

• Primary citation: Poy, F.,Yaffe, M.B.,Sayos, J.,Saxena, K.,Morra, M.,Sumegi, J.,Cantley, L.C.,Terhorst, C.,Eck, M.J.; Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.; Mol.Cell, 4:555-561, 1999; PubMed: 10549287; DOI: 10.1016/S1097-2765(00)80206-3

Experimental method

X-RAY DIFFRACTION (1.8 Å)