1D4K
HIV-1 PROTEASE COMPLEXED WITH A MACROCYCLIC PEPTIDOMIMETIC INHIBITOR
Summary for 1D4K
Entry DOI | 10.2210/pdb1d4k/pdb |
Related | 1b6k 1b6m |
Descriptor | HIV-1 PROTEASE, SULFATE ION, N-13-[(10S,13S)-9,12-DIOXO-10-(2-BUTYL)-2-OXA-8,11-DIAZABICYCLO [13.2.2] NONADECA-15,17,18-TRIENE] (2R)-BENZYL-(4S)-HYDROXY-5-AMINOPENTANOIC (1R)-HYDROXY-(2S)-INDANEAMIDE, ... (4 entities in total) |
Functional Keywords | hiv, protease, inhibitor, antiviral, hydrolase |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369 |
Total number of polymer chains | 2 |
Total formula weight | 22422.39 |
Authors | Tyndall, J.D.,Reid, R.C.,Tyssen, D.P.,Jardine, D.K.,Todd, B.,Passmore, M.,March, D.R.,Pattenden, L.K.,Alewood, D.,Hu, S.H.,Alewood, P.F.,Birch, C.J.,Martin, J.L.,Fairlie, D.P. (deposition date: 1999-10-04, release date: 2000-10-11, Last modification date: 2021-11-03) |
Primary citation | Tyndall, J.D.,Reid, R.C.,Tyssen, D.P.,Jardine, D.K.,Todd, B.,Passmore, M.,March, D.R.,Pattenden, L.K.,Bergman, D.A.,Alewood, D.,Hu, S.H.,Alewood, P.F.,Birch, C.J.,Martin, J.L.,Fairlie, D.P. Synthesis, stability, antiviral activity, and protease-bound structures of substrate-mimicking constrained macrocyclic inhibitors of HIV-1 protease. J.Med.Chem., 43:3495-3504, 2000 Cited by PubMed: 11000004DOI: 10.1021/jm000013n PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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