1D4K

HIV-1 PROTEASE COMPLEXED WITH A MACROCYCLIC PEPTIDOMIMETIC INHIBITOR

1D4K の概要

• エントリーDOI: 10.2210/pdb1d4k/pdb
• 関連するPDBエントリー: 1b6k 1b6m
• 分子名称: HIV-1 PROTEASE, SULFATE ION, N-13-[(10S,13S)-9,12-DIOXO-10-(2-BUTYL)-2-OXA-8,11-DIAZABICYCLO [13.2.2] NONADECA-15,17,18-TRIENE] (2R)-BENZYL-(4S)-HYDROXY-5-AMINOPENTANOIC (1R)-HYDROXY-(2S)-INDANEAMIDE, ... (4 entities in total)
• 機能のキーワード: hiv, protease, inhibitor, antiviral, hydrolase
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22422.39

構造登録者

Tyndall, J.D.,Reid, R.C.,Tyssen, D.P.,Jardine, D.K.,Todd, B.,Passmore, M.,March, D.R.,Pattenden, L.K.,Alewood, D.,Hu, S.H.,Alewood, P.F.,Birch, C.J.,Martin, J.L.,Fairlie, D.P. (登録日: 1999-10-04, 公開日: 2000-10-11, 最終更新日: 2021-11-03)

• 主引用文献: Tyndall, J.D.,Reid, R.C.,Tyssen, D.P.,Jardine, D.K.,Todd, B.,Passmore, M.,March, D.R.,Pattenden, L.K.,Bergman, D.A.,Alewood, D.,Hu, S.H.,Alewood, P.F.,Birch, C.J.,Martin, J.L.,Fairlie, D.P.; Synthesis, stability, antiviral activity, and protease-bound structures of substrate-mimicking constrained macrocyclic inhibitors of HIV-1 protease.; J.Med.Chem., 43:3495-3504, 2000; PubMed: 11000004; DOI: 10.1021/jm000013n

実験手法

X-RAY DIFFRACTION (1.85 Å)