1CVS

CRYSTAL STRUCTURE OF A DIMERIC FGF2-FGFR1 COMPLEX

1CVS の概要

• エントリーDOI: 10.2210/pdb1cvs/pdb
• 分子名称: FIBROBLAST GROWTH FACTOR 2, FIBROBLAST GROWTH FACTOR RECEPTOR 1, SULFATE ION (3 entities in total)
• 機能のキーワード: fgf, fgfr, immunoglobulin-like, signal transduction, dimerization, growth factor-growth factor receptor complex, growth factor/growth factor receptor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P11362
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 81154.54

構造登録者

Plotnikov, A.N.,Schlessinger, J.,Hubbard, S.R.,Mohammadi, M. (登録日: 1999-08-24, 公開日: 2000-01-28, 最終更新日: 2024-11-20)

主引用文献

Plotnikov, A.N.,Schlessinger, J.,Hubbard, S.R.,Mohammadi, M.
Structural basis for FGF receptor dimerization and activation.
Cell(Cambridge,Mass.), 98:641-650, 1999

PubMed Abstract: The crystal structure of FGF2 bound to a naturally occurring variant of FGF receptor 1 (FGFR1) consisting of immunoglobulin-like domains 2 (D2) and 3 (D3) has been determined at 2.8 A resolution. Two FGF2:FGFR1 complexes form a 2-fold symmetric dimer. Within each complex, FGF2 interacts extensively with D2 and D3 as well as with the linker between the two domains. The dimer is stabilized by interactions between FGF2 and D2 of the adjoining complex and by a direct interaction between D2 of each receptor. A positively charged canyon formed by a cluster of exposed basic residues likely represents the heparin-binding site. A general model for FGF- and heparin-induced FGFR dimerization is inferred from the crystal structure, unifying a wealth of biochemical data.

PubMed: 10490103
DOI: 10.1016/S0092-8674(00)80051-3

実験手法

X-RAY DIFFRACTION (2.8 Å)