1CTO
NMR STRUCTURE OF THE C-TERMINAL DOMAIN OF THE LIGAND-BINDING REGION OF MURINE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR, MINIMIZED AVERAGE STRUCTURE
Summary for 1CTO
| Entry DOI | 10.2210/pdb1cto/pdb |
| Descriptor | GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR (1 entity in total) |
| Functional Keywords | binding protein, cytokine receptor |
| Biological source | Mus musculus (house mouse) |
| Cellular location | Membrane; Single-pass type I membrane protein: P40223 |
| Total number of polymer chains | 1 |
| Total formula weight | 12536.45 |
| Authors | Yamasaki, K.,Naito, S.,Anaguchi, H.,Ohkubo, T.,Ota, Y. (deposition date: 1996-09-25, release date: 1997-10-22, Last modification date: 2024-10-23) |
| Primary citation | Yamasaki, K.,Naito, S.,Anaguchi, H.,Ohkubo, T.,Ota, Y. Solution structure of an extracellular domain containing the WSxWS motif of the granulocyte colony-stimulating factor receptor and its interaction with ligand. Nat.Struct.Biol., 4:498-504, 1997 Cited by PubMed Abstract: We have determined the NMR structure of a ligand-binding domain of the granulocyte colony-stimulating factor (G-CSF) receptor, containing the highly conserved WSxWS motif. The domain consists of seven beta-strands with the fibronectin type III-like topology seen in several cytokine receptors. Comparisons between the spectra of the 15N-labelled domain with and without G-CSF indicate that the major ligand-recognition site is on the FG loop just upstream of the WSxWS sequence, and not on the BC loop which is mainly used in the growth hormone system. The WSxWS residues are suggested to contribute to ligand-recognition and to the protein architecture of the G-CSF receptor. PubMed: 9187659DOI: 10.1038/nsb0697-498 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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