1CSS

ALPHA-FLUORO ACID AND ALPHA-FLUORO AMIDE ANALOGS OF ACETYL-COA AS INHIBITORS OF OF CITRATE SYNTHASE: EFFECT OF PKA MATCHING ON BINDING AFFINITY AND HYDROGEN BOND LENGTH

Summary for 1CSS

Entry DOI	10.2210/pdb1css/pdb
Descriptor	CITRATE SYNTHASE, OXALOACETATE ION, ALPHA-FLUORO-CARBOXYMETHYLDETHIA COENZYME A COMPLEX, ... (4 entities in total)
Functional Keywords	oxo-acid-lyase
Biological source	Gallus gallus (chicken)
Cellular location	Mitochondrion matrix: P23007
Total number of polymer chains	1
Total formula weight	49117.49
Authors	Usher, K.C.,Remington, S.J. (deposition date: 1995-08-04, release date: 1995-10-15, Last modification date: 2024-02-07)
Primary citation	Schwartz, B.,Drueckhammer, D.G.,Usher, K.C.,Remington, S.J. alpha-Fluoro acid and alpha-fluoro amide analogs of acetyl-CoA as inhibitors of citrate synthase: effect of pKa matching on binding affinity and hydrogen bond length. Biochemistry, 34:15459-15466, 1995 Cited by PubMed: 7492547 DOI: 10.1021/bi00047a010 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation