1CSB

Crystal structure of cathepsin b inhibited with CA030 at 2.1 angstroms resolution: A basis for the design of specific epoxysuccinyl inhibitors

1CSB の概要

• エントリーDOI: 10.2210/pdb1csb/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000310
• 分子名称: CATHEPSIN B light chain, CATHEPSIN B heavy chain, N-[(3R)-4-ethoxy-3-hydroxy-4-oxobutanoyl]-L-isoleucyl-L-proline, ... (4 entities in total)
• 機能のキーワード: papain-like lysosomal dicarboxy-peptidase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Lysosome: P07858 P07858
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 56048.33

構造登録者

Turk, D.,Bode, W. (登録日: 1994-12-09, 公開日: 1996-04-03, 最終更新日: 2012-12-12)

• 主引用文献: Turk, D.,Podobnik, M.,Popovic, T.,Katunuma, N.,Bode, W.,Huber, R.,Turk, V.; Crystal structure of cathepsin B inhibited with CA030 at 2.0-A resolution: A basis for the design of specific epoxysuccinyl inhibitors.; Biochemistry, 34:4791-4797, 1995; PubMed: 7718586; DOI: 10.1021/bi00014a037

実験手法

X-RAY DIFFRACTION (2 Å)