1CM8

PHOSPHORYLATED MAP KINASE P38-GAMMA

1CM8 の概要

• エントリーDOI: 10.2210/pdb1cm8/pdb
• 分子名称: PHOSPHORYLATED MAP KINASE P38-GAMMA, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (4 entities in total)
• 機能のキーワード: p38-gamma, gamma, phosphorylation, map kinase, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P53778
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 85423.79

構造登録者

Bellon, S.,Fitzgibbon, M.J.,Fox, T.,Hsiao, H.M.,Wilson, K.P. (登録日: 1999-05-17, 公開日: 2000-05-17, 最終更新日: 2024-11-20)

主引用文献

Bellon, S.,Fitzgibbon, M.J.,Fox, T.,Hsiao, H.M.,Wilson, K.P.
The structure of phosphorylated p38gamma is monomeric and reveals a conserved activation-loop conformation.
Structure Fold.Des., 7:1057-1065, 1999

PubMed Abstract: Mitogen-activated protein (MAP) kinases mediate the cellular response to stimuli such as pro-inflammatory cytokines and environmental stress. P38gamma is a new member of the MAP kinase family, and is expressed at its highest levels in skeletal muscle. P38gamma is 63% identical in sequence to P38alpha. The structure of P38alpha MAP kinase has been determined in the apo, unphosphorylated, inactive form. The structures of apo unphosphorylated ERK2, a related MAP kinase, and apo phosphorylated ERK2 have also been determined.

PubMed: 10508788
DOI: 10.1016/S0969-2126(99)80173-7

実験手法

X-RAY DIFFRACTION (2.4 Å)