1CJB

MALARIAL PURINE PHOSPHORIBOSYLTRANSFERASE

1CJB の概要

• エントリーDOI: 10.2210/pdb1cjb/pdb
• 分子名称: PROTEIN (HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE), MAGNESIUM ION, (1S)-1(9-DEAZAHYPOXANTHIN-9YL)1,4-DIDEOXY-1,4-IMINO-D-RIBITOL-5-PHOSPHATE, ... (5 entities in total)
• 機能のキーワード: malaria, purine salvage, phosphoribosyltransferase, transition state inhibitor, transferase
• 由来する生物種: Plasmodium falciparum (malaria parasite P. falciparum)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 107829.04

構造登録者

Shi, W.,Li, C.M.,Tyler, P.C.,Furneaux, R.H.,Cahill, S.M.,Girvin, M.E.,Grubmeyer, C.,Schramm, V.L.,Almo, S.C. (登録日: 1999-04-08, 公開日: 1999-08-18, 最終更新日: 2023-08-09)

• 主引用文献: Shi, W.,Li, C.M.,Tyler, P.C.,Furneaux, R.H.,Cahill, S.M.,Girvin, M.E.,Grubmeyer, C.,Schramm, V.L.,Almo, S.C.; The 2.0 A structure of malarial purine phosphoribosyltransferase in complex with a transition-state analogue inhibitor.; Biochemistry, 38:9872-9880, 1999; PubMed: 10433693; DOI: 10.1021/bi990664p

実験手法

X-RAY DIFFRACTION (2 Å)