1CJ1

GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN (HUMAN) COMPLEXED WITH A PHOSPHOTYROSYL DERIVATIVE

1CJ1 の概要

• エントリーDOI: 10.2210/pdb1cj1/pdb
• 分子名称: PROTEIN (GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2), [1-[1-(6-CARBAMOYL-CYCLOHEX-2-ENYLCARBAMOYL)-CYCLOHEXYLCARBAMOYL]-2-(4-PHOSPHONOOXY-PHENYL)- ETHYL]-CARBAMIC ACID 3-AMINOBENZYLESTER (3 entities in total)
• 機能のキーワード: signal transduction, sh2 domain, phosphotyrosine, signaling protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus : P62993
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 142155.80

構造登録者

Rahuel, J. (登録日: 1999-04-21, 公開日: 1999-12-22, 最終更新日: 2023-08-02)

主引用文献

Furet, P.,Garcia-Echeverria, C.,Gay, B.,Schoepfer, J.,Zeller, M.,Rahuel, J.
Structure-based design, synthesis, and X-ray crystallography of a high-affinity antagonist of the Grb2-SH2 domain containing an asparagine mimetic.
J.Med.Chem., 42:2358-2363, 1999

PubMed Abstract: Previous efforts in the search for molecules capable of blocking the associations between the activated tyrosine kinase growth factor receptors and the SH2 domain of Grb2 had resulted in the identification of 3-amino-Z-pTyr-Ac6c-Asn-NH2, a high-affinity and selective antagonist of this SH2 domain. In the present paper, we report the successful replacement of asparagine in this compound by a beta-amino acid mimetic, which brings us closer to our objective of identifying a Grb2-SH2 antagonist suitable for pharmacological investigations.

PubMed: 10395476
DOI: 10.1021/jm991013u

実験手法

X-RAY DIFFRACTION (3 Å)