1CI7

TERNARY COMPLEX OF THYMIDYLATE SYNTHASE FROM PNEUMOCYSTIS CARINII

1CI7 の概要

• エントリーDOI: 10.2210/pdb1ci7/pdb
• 分子名称: PROTEIN (THYMIDYLATE SYNTHASE), 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, ... (4 entities in total)
• 機能のキーワード: methyltransferase, nucleotide biosynthesis, half-sites reactivity, transferase
• 由来する生物種: Pneumocystis carinii
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 69900.40

構造登録者

Anderson, A.C.,O'Neil, R.H.,Delano, W.L.,Stroud, R.M. (登録日: 1999-04-08, 公開日: 2000-04-10, 最終更新日: 2024-04-03)

• 主引用文献: Anderson, A.C.,O'Neil, R.H.,DeLano, W.L.,Stroud, R.M.; The structural mechanism for half-the-sites reactivity in an enzyme, thymidylate synthase, involves a relay of changes between subunits.; Biochemistry, 38:13829-13836, 1999; PubMed: 10529228; DOI: 10.1021/bi991610i

実験手法

X-RAY DIFFRACTION (2.6 Å)