1CDK

CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT (E.C.2.7.1.37) (PROTEIN KINASE A) COMPLEXED WITH PROTEIN KINASE INHIBITOR PEPTIDE FRAGMENT 5-24 (PKI(5-24) ISOELECTRIC VARIANT CA) AND MN2+ ADENYLYL IMIDODIPHOSPHATE (MNAMP-PNP) AT PH 5.6 AND 7C AND 4C

1CDK の概要

• エントリーDOI: 10.2210/pdb1cdk/pdb
• 分子名称: CAMP-DEPENDENT PROTEIN KINASE, PROTEIN KINASE INHIBITOR, MANGANESE (II) ION, ... (6 entities in total)
• 機能のキーワード: complex (transferase-inhibitor), transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Sus scrofa (pig); 詳細
• 細胞内の位置: Cytoplasm: P00517
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 87392.52

構造登録者

Bossemeyer, D.,Engh, R.A.,Kinzel, V.,Ponstingl, H.,Huber, R. (登録日: 1994-07-04, 公開日: 1995-10-15, 最終更新日: 2012-07-18)

• 主引用文献: Bossemeyer, D.,Engh, R.A.,Kinzel, V.,Ponstingl, H.,Huber, R.; Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24).; EMBO J., 12:849-859, 1993; PubMed: 8384554

実験手法

X-RAY DIFFRACTION (2 Å)