1CBR

CRYSTAL STRUCTURE OF CELLULAR RETINOIC-ACID-BINDING PROTEINS I AND II IN COMPLEX WITH ALL-TRANS-RETINOIC ACID AND A SYNTHETIC RETINOID

1CBR の概要

• エントリーDOI: 10.2210/pdb1cbr/pdb
• 分子名称: CELLULAR RETINOIC ACID BINDING PROTEIN TYPE I, RETINOIC ACID (3 entities in total)
• 機能のキーワード: retinoic-acid transport
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 31561.65

構造登録者

Kleywegt, G.J.,Bergfors, T.,Jones, T.A. (登録日: 1994-09-28, 公開日: 1995-01-26, 最終更新日: 2024-02-07)

主引用文献

Kleywegt, G.J.,Bergfors, T.,Senn, H.,Le Motte, P.,Gsell, B.,Shudo, K.,Jones, T.A.
Crystal structures of cellular retinoic acid binding proteins I and II in complex with all-trans-retinoic acid and a synthetic retinoid.
Structure, 2:1241-1258, 1994

PubMed Abstract: Retinoic acid (RA) plays a fundamental role in diverse cellular activities. Cellular RA binding proteins (CRABPs) are thought to act by modulating the amount of RA available to nuclear RA receptors. CRABPs and cellular retinol-binding proteins (CRBPs) share a unique fold of two orthogonal beta-sheets that encapsulate their ligands. It has been suggested that a trio of residues are the prime determinants defining the high specificity of CRBPs and CRABPs for their physiological ligands.

PubMed: 7704533
DOI: 10.1016/S0969-2126(94)00125-1

実験手法

X-RAY DIFFRACTION (2.9 Å)