1CA0

BOVINE CHYMOTRYPSIN COMPLEXED TO APPI

Summary for 1CA0

Entry DOI	10.2210/pdb1ca0/pdb
Descriptor	BOVINE CHYMOTRYPSIN, PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR, ... (5 entities in total)
Functional Keywords	serine protease, inhibitor, protease-substrate interactions, complex (serine protease-inhibitor), complex (serine protease-inhibitor) complex, complex (serine protease/inhibitor)
Biological source	Bos taurus (cattle) More
Cellular location	Secreted, extracellular space: P00766 P00766 P00766 Membrane; Single-pass type I membrane protein: P05067
Total number of polymer chains	8
Total formula weight	62536.46
Authors	Scheidig, A.J.,Kossiakoff, A.A. (deposition date: 1997-01-23, release date: 1997-07-23, Last modification date: 2011-07-13)
Primary citation	Scheidig, A.J.,Hynes, T.R.,Pelletier, L.A.,Wells, J.A.,Kossiakoff, A.A. Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities. Protein Sci., 6:1806-1824, 1997 Cited by PubMed: 9300481 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation