1C9H

CRYSTAL STRUCTURE OF FKBP12.6 IN COMPLEX WITH RAPAMYCIN

1C9H の概要

• エントリーDOI: 10.2210/pdb1c9h/pdb
• 関連するPDBエントリー: 1FAP 1FKL
• 分子名称: FKBP12.6, RAPAMYCIN IMMUNOSUPPRESSANT DRUG (3 entities in total)
• 機能のキーワード: fkbp12, rapamycin, complex, ryanodine receptor, immune system
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 12581.48

構造登録者

Deivanayagam, C.C.S.,Carson, M.,Thotakura, A.,Narayana, S.V.L.,Chodavarapu, C.S. (登録日: 1999-08-02, 公開日: 2000-08-03, 最終更新日: 2024-02-07)

主引用文献

Deivanayagam, C.C.,Carson, M.,Thotakura, A.,Narayana, S.V.,Chodavarapu, R.S.
Structure of FKBP12.6 in complex with rapamycin.
Acta Crystallogr.,Sect.D, 56:266-271, 2000

PubMed Abstract: FKBP12.6 is a novel isoform of FKBP12, which selectively binds to the cardiac ryanodine receptor (RyR2). The crystal structure of FKBP12.6 in complex with rapamycin has now been determined at 2.0 A resolution. The structures of FKBP12.6 and FKBP12 are nearly identical, except for a displacement observed in the helical region of FKBP12.6 toward the hydrophobic pocket. This displacement was not predicted by homology modeling studies. Analyses of the residues that are likely to confer the RyR2-binding specificity are presented.

PubMed: 10713512
DOI: 10.1107/S0907444999016571

実験手法

X-RAY DIFFRACTION (2 Å)