1C9H

CRYSTAL STRUCTURE OF FKBP12.6 IN COMPLEX WITH RAPAMYCIN

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002027	biological_process	regulation of heart rate
A	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
A	0005102	molecular_function	signaling receptor binding
A	0005246	molecular_function	calcium channel regulator activity
A	0005515	molecular_function	protein binding
A	0005528	molecular_function	FK506 binding
A	0005737	cellular_component	cytoplasm
A	0006458	biological_process	'de novo' protein folding
A	0006939	biological_process	smooth muscle contraction
A	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
A	0009749	biological_process	response to glucose
A	0010459	biological_process	negative regulation of heart rate
A	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A	0016020	cellular_component	membrane
A	0016529	cellular_component	sarcoplasmic reticulum
A	0016853	molecular_function	isomerase activity
A	0019227	biological_process	neuronal action potential propagation
A	0019722	biological_process	calcium-mediated signaling
A	0019855	molecular_function	calcium channel inhibitor activity
A	0030018	cellular_component	Z disc
A	0030073	biological_process	insulin secretion
A	0033017	cellular_component	sarcoplasmic reticulum membrane
A	0034704	cellular_component	calcium channel complex
A	0035773	biological_process	insulin secretion involved in cellular response to glucose stimulus
A	0042026	biological_process	protein refolding
A	0042098	biological_process	T cell proliferation
A	0044325	molecular_function	transmembrane transporter binding
A	0050849	biological_process	negative regulation of calcium-mediated signaling
A	0051209	biological_process	release of sequestered calcium ion into cytosol
A	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
A	0051284	biological_process	positive regulation of sequestering of calcium ion
A	0051604	biological_process	protein maturation
A	0051775	biological_process	response to redox state
A	0061179	biological_process	negative regulation of insulin secretion involved in cellular response to glucose stimulus

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE RAP A 108

Chain	Residue
A	THR6
A	VAL55
A	ILE56
A	PHE59
A	TYR82
A	HIS87
A	PHE99
A	ASP100
A	HOH165
A	HOH199
A	TYR26
A	THR27
A	LYS35
A	PHE36
A	ASP37
A	PHE46
A	GLN53
A	GLU54

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	88
Details	Domain: {"description":"PPIase FKBP-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00277","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1d6o

Chain	Residue	Details
A	ILE56
A	TYR82
A	ASP37

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