1C86
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B (R47V,D48N) COMPLEXED WITH 2-(OXALYL-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID
Summary for 1C86
Entry DOI | 10.2210/pdb1c86/pdb |
Related | 1C83 1C84 1C85 1C87 1C88 1ECV |
Descriptor | PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B), 2-(OXALYL-AMINO)-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID (3 entities in total) |
Functional Keywords | hydrolase, phosphorylation, ligand, inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031 |
Total number of polymer chains | 1 |
Total formula weight | 34932.77 |
Authors | Iversen, L.F.,Andersen, H.S.,Mortensen, S.B.,Moller, N.P. (deposition date: 2000-04-16, release date: 2000-05-03, Last modification date: 2023-08-09) |
Primary citation | Iversen, L.F.,Andersen, H.S.,Branner, S.,Mortensen, S.B.,Peters, G.H.,Norris, K.,Olsen, O.H.,Jeppesen, C.B.,Lundt, B.F.,Ripka, W.,Moller, K.B.,Moller, N.P. Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B. J.Biol.Chem., 275:10300-10307, 2000 Cited by PubMed: 10744717DOI: 10.1074/jbc.275.14.10300 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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