1C6Z

ALTERNATE BINDING SITE FOR THE P1-P3 GROUP OF A CLASS OF POTENT HIV-1 PROTEASE INHIBITORS AS A RESULT OF CONCERTED STRUCTURAL CHANGE IN 80'S LOOP.

Summary for 1C6Z

• Entry DOI: 10.2210/pdb1c6z/pdb
• Related: 1c6x 1c6y 1c70
• Related PRD ID: PRD_000454
• Descriptor: PROTEIN (PROTEASE), (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide (3 entities in total)
• Functional Keywords: hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 2
• Total formula weight: 22274.19

Authors

Munshi, S. (deposition date: 1999-12-28, release date: 2000-12-28, Last modification date: 2023-12-27)

• Primary citation: Munshi, S.,Chen, Z.,Yan, Y.,Li, Y.,Olsen, D.B.,Schock, H.B.,Galvin, B.B.,Dorsey, B.,Kuo, L.C.; An alternate binding site for the P1-P3 group of a class of potent HIV-1 protease inhibitors as a result of concerted structural change in the 80s loop of the protease.; Acta Crystallogr.,Sect.D, 56:381-388, 2000; PubMed: 10739910; DOI: 10.1107/S0907444900000469

Experimental method

X-RAY DIFFRACTION (2.5 Å)