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1C5H

HYDROGEN BONDING AND CATALYSIS: AN UNEXPECTED EXPLANATION FOR HOW A SINGLE AMINO ACID SUBSTITUTION CAN CHANGE THE PH OPTIMUM OF A GLYCOSIDASE

Summary for 1C5H
Entry DOI10.2210/pdb1c5h/pdb
DescriptorENDO-1,4-BETA-XYLANASE (2 entities in total)
Functional Keywordsglycosidase, ph-dependent enzyme mechanism, general acid/ base catalysis, x-ray cyrstallography, isotope shift, short hydrogen bonds, xylan, hydrolase
Biological sourceBacillus circulans
Total number of polymer chains1
Total formula weight20409.99
Authors
Joshi, M.D.,Sidhu, G.,Pot, I.,Brayer, G.D.,Withers, S.G.,Mcintosh, L.P. (deposition date: 1999-11-24, release date: 2000-05-12, Last modification date: 2023-12-27)
Primary citationJoshi, M.D.,Sidhu, G.,Pot, I.,Brayer, G.D.,Withers, S.G.,McIntosh, L.P.
Hydrogen bonding and catalysis: a novel explanation for how a single amino acid substitution can change the pH optimum of a glycosidase.
J.Mol.Biol., 299:255-279, 2000
Cited by
PubMed: 10860737
DOI: 10.1006/jmbi.2000.3722
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.55 Å)
Structure validation

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